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A2M, alpha 2 macroglobulin, Pain,

A2M (Alpha 2 Macroglobulin)

A2M (Alpha 2 macroglobulin) is a natural powerful healing molecule that is present in our own blood and is our body’s major defense mechanism against arthritis and degeneration of the spine and joints. It is mainly produced by the liver, and also locally synthesized by macrophages, fibroblasts, and adrenocortical cells. 


A2M is used to prevent cartilage breakdown in patients, promote tissue growth and support the overall restoration of an affected joint. In concentrated doses, A2M acts as a powerful protector against cartilage and spinal disc breakdown and further degeneration. A2M also has growth hormone binding sites which can aid in the restoration of joints and discs. This is a superior example of how regenerative medicine treatments activate the body’s own natural healing mechanisms to repair and restore without incisions, trauma, general anesthesia or the lengthy recovery period that is common with surgery. 


Unlike pain medications which simply mask pain symptoms and have multiple side effects; A2M addresses and treats the underlying causes of the pain conditions, naturally. 


Overall benefits to A2M treatments: 

  •  Relieve pain 
  •  Promote tissue growth
  •  Support overall joint restoration


Some patients may require only one treatment while others may require repeat treatments. It depends on a patient’s specific conditions and how severe the injury is. Often, patients come for regenerative medicine treatments after they have developed a significant degenerative condition and have tried multiple other treatment protocols

Types of Conditions Treated with A2M


  • Osteoarthritis and degenerative conditions of the shoulder, wrist, hip, knee and ankle
  • Degenerative disc disease 
  • Disc herniations 
  • Annular tears
  • Sport injuries 
  • Damaged or injured cartilages
  • Ligament sprains or tears 
  • Rotator cuff injuries
  • Joint and tendon injuries 
  • Plantar fasciitis 
  • Muscle injuries 
  • Cervical and Lumbar radiculopathy (sciatica) 
  • Tendinitis